Lys-[Des-Arg9]Bradykinin

CAS: 71800-36-7 F: C50H73N13O11 W: 1032.20

Lys-Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki o

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Bioactivity	Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors[1][2].
Invitro	Lys-[Des-Arg9]Bradykinin 由缓激肽的蛋白水解裂解形成，通过缓激肽 B1 受体 (B1R) 发挥作用[1]。Lys-[Des-Arg9]Bradykinin (Lda-BK; 10 μM) 增强 IL-12p70 的分泌并抑制成熟 hMo-DC 的 IL-12p40 分泌。用 Lys-[Des-Arg9]Bradykinin 预处理可减少成熟 hMo-DC 单独向培养基的迁移，表明 Lys-[Des-Arg9]Bradykinin 可抑制成熟 hMo-DC 的趋化作用[1]。
In Vivo	Lys-[Des-Arg9]Bradykinin (1 μg；鼻腔注射；新西兰大白兔) 处理可降低脂多糖诱导家兔外周血管阻力，但效果短暂(T1/2=118-195 s)[3]。
Name	Lys-[Des-Arg9]Bradykinin
CAS	71800-36-7
Sequence	Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe
Shortening	KRPPGFSPF
Formula	C50H73N13O11
Molar Mass	1032.20
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Rosalind Gulliver, et al. Lys-des[Arg9]-bradykinin alters migration and production of interleukin-12 in monocyte-derived dendritic cells. Am J Respir Cell Mol Biol. 2011 Sep;45(3):542-9. [2]. L M Fredrik Leeb-Lundberg, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77. [3]. G Drapeau, et al. Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. J Pharmacol Exp Ther. 1991 Dec;259(3):997-1003.

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